An elevated D-dimer level is found after a clot has formed and is in the process of breaking down. A negative D-dimer test means that a blood clot is highly unlikely.

D-dimer is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link.

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